Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002241" target="_blank" >RIV/61989592:15310/04:00002241 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/04:00000835
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin
Original language description
Flavonoids are found universally in plants and act as free radical scavenging and chelating agents with anti-inflammatory, antiischemic, vasodilating and chemoprotective properties. In this study, the antilipoperoxidative and cytoprotective effects of apigenin, baicalein, kaempferol, luteolin and quercetin against doxorubic-ininduced oxidative stress were investigated in isolated rat heart cardiac myocytes, mitochondria and microsomes. After preincubation of cardiomyocytes with the test compounds for 1It the cardiomyocytes were treated with the toxic agent, doxorubicin (100 muM for 8 h). Cardiomyocyte protection was assessed by extracellular LDH and cellular ADP and ATP production. Cytoprotection was concentration dependent for baicalein > luteolin congruent to apigenin > quercetin > kaempferol. All test compounds had significantly better protective effects than dexrazoxan, an agent currently used for adjuvant therapy during anthracycline antibiotic therapy. In microsomes/ mitochondri
Czech name
Ochranný efekt rostlinných fenolických látek proti toxicitě vyvolané anthracyklinem na krysích kardiomyocytech. Část III. Apigenin, baicalelin, kaempherol, luteolin a quercetin
Czech description
Studie se věnuje ochrannému efektu rostlinných fenolických látek proti toxicitě vyvolané anthracyklinem na krysích kardiomyocytech. Tato již III.část je zaměřena na Apigenin, baicalelin, kaempherol, luteolin a quercetin.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Phytotherapy Research
ISSN
0951-418X
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
516-521
UT code for WoS article
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EID of the result in the Scopus database
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