The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00004912" target="_blank" >RIV/61989592:15310/07:00004912 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/07:00009751

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

Original language description

The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast cancer. ATM signalling is constitutively activated in early stages of diverse types of human malignancies and cell culture models in response to oncogene-induced DNA damage providing a barrier against tumour progression. As BRCA1 and BRCA2 are also components of the genome maintenance network and their mutations predispose to breast cancer, we have examined the ATM expression in human breast carcinomas of BRCA1/2 mutation carriers, sporadic cases and familial non-BRCA1/2 patients. Our results show that ATM protein expression is aberrantly reduced more frequently among BRCA1 (33%; P=0.0003) and BRCA2 (30%; P=0.0009) tumours than in non-BRCA1/2 tumours (10.7%). Furthermore, the non-BRCA1/2 tumours with reduced ATM expression were more often estrogen receptor (ER) negative (P=0.0002),

Czech name

Kinasa ATM signalizující poškození DNA chybí nebo je redukovaná u BRCA1/BRCA2-deficientní a ER/PR/ERBB2-triple-negativní rakoviny prsu

Czech description

Navrhujeme model "příležitostné haploinsuficience" pro BRCA1/2 v podmínkách rozšířeného poškození DNA v prekancerogenních lezích, která vede k robustnější aktivaci a proto také zvýšenému výběru k inaktivaci nebo ztrátě ATM v tumorech s BRCA1/2 mutací, zahrnující v sobě zvýšenou genomickou nestabilitu a léčitelnost různých subsystémů lídské rakoviny prsu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncogene

ISSN

0950-9232

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

10.1038

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

1-6

UT code for WoS article

—

EID of the result in the Scopus database

—