DNA damage signalling guards against activated oncogenes and tumour progression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00004918" target="_blank" >RIV/61989592:15310/07:00004918 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/07:00009750

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

DNA damage signalling guards against activated oncogenes and tumour progression

Original language description

DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against progression of cancer beyond its early stages. Recent evidence from both cell culture and animal models as well as analyses of clinical specimens show that activation of numerous oncogenes and loss of some tumour suppressors result in DNA replication stress and DNA damage that alarm the cellular DDR machinery, a multifaceted response orchestrated by the ATR?Chk1 and ATM?Chk2 kinase signalling pathways. Such activation of the DDR network leads to cellular senescence or death of oncogene-transformed cells, resulting in delay or prevention of tumorigenesis. At the same time, the ongoing chronic DDR activation creates selective pressurethat eventually favours outgrowth of malignant clones with genetic or epigenetic defects in the genome maintenance machinery, such as aberrations in the ATM?Chk2?p53 cascade and other DDR components. Furthermore, the executive DDR machin

Czech name

Ochranná signalizace poškození DNA proti aktivvaným onkogenům a progresi tumoru

Czech description

Odezva poškození DNA (DNA damage response (DDR)), strážce genové integrity, vystupuje jako onkogenem indukovatelná bariéra proti rozvinutí rakoviny po jejích časných stadiích. V této studii poukazujeme na nejnovější poznatky v této rychle se rozvíjejícíoblasti výzkumu rakoviny, se zvláštním zřetelem na mechanistický pohled, největší objevy a použití modelu DDR jako bariéry proti vývoji tumoru pro experimentální i klinickou onkologii.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncogene

ISSN

0950-9232

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

56

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

7773-7779

UT code for WoS article

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EID of the result in the Scopus database

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