Role of DNA repair in antitumor effects of platinum drugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00005499" target="_blank" >RIV/61989592:15310/09:00005499 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Role of DNA repair in antitumor effects of platinum drugs
Original language description
Designing more efficient antitumor platinum-based drugs depends on understanding details of how cells process the existing platinum agents. There is a large body of experimental evidence that the success of platinum complexes in killing tumor cells results from their ability to damage DNA by forming various types of covalent adducts. The adducts formed by platinum antitumor drugs cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to replicate and transcribe the gene that the affected DNA encodes. After DNA is modified by platinum drugs, cellular repair systems recognize this damage. Consequently, the DNA repair process is constantly active as it responds to damage in the DNA structure caused by platinum antitumordrugs. The purpose of this review is to highlight recent discoveries in those pathways triggering tumor cell death that are involved in repairing platinated DNA. The topics discussed in this review do not involve mechanisms underlying rep
Czech name
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Czech description
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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