Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010070" target="_blank" >RIV/61989592:15310/09:00010070 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors
Original language description
This work represents a continuation of our systematic research of transition metal complexes with N6-benzyadenine derivatives. It deals with synthesis, characterization and in vitro cytotoxicity of the platinum(II) and palldium(II) oxalato complexes of the general formula [Pt(L)2(ox)] and [Pd(L)2(ox)], where L stands for a molecule of the cyclin-dependent kinase (CDK) inhibitor of N6-benzyl-9-isopropyladenine moiety. The complexes have been synthesized by a reaction of K2[M(ox)2].2H2O (M = Pt or Pd) with two molar equivalents of the appropriate L organic compounds. The prepared complexes have been fully characterized by varied methods including multinuclear NMR spectroscopy and single-crystal X ray analysis. The geometry of complexes is square planar with tetra-coordinated central transition metal ion and PtN2O2/PdN2O2 donor set. Two L molecules are coordinated through N7 atoms of thein purine moieties. Some of the complexes have shown significant in vitro cytotoxic properties against
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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