Cyclocondensation Reaction of Heterocyclic Carbonyl Compounds XIII. Synthesis and Cytotoxic Activity of Some 3,7-Diaryl-5-(3,4,5-trimethoxyphenyl)-pyrazolo [4,3-e] [1,2,4] triazines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010317" target="_blank" >RIV/61989592:15310/09:00010317 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cyclocondensation Reaction of Heterocyclic Carbonyl Compounds XIII. Synthesis and Cytotoxic Activity of Some 3,7-Diaryl-5-(3,4,5-trimethoxyphenyl)-pyrazolo [4,3-e] [1,2,4] triazines
Original language description
A series of the 3,7-diaryl-5-(3,4,5-trimethoxyphenyl) pyrazolo[4,3-e][1,2,4]triazines (17a-20f) has been synthesized in five steps. The cytotoxic activity of all of the newly synthesized compounds has been tested in vitro against five cancer cell lines.Several compounds demonstrated significant broad cytotoxic activity in low micromolar range, while others were selective active against lung adenocarcinoma cell line A549.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Medicinal Chemistry
ISSN
0223-5234
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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