Semisynthetic Lupane Triterpenes with Cytotoxic Activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10215489" target="_blank" >RIV/61989592:15310/10:10215489 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/10:00355519 RIV/61388963:_____/10:00355519
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Semisynthetic Lupane Triterpenes with Cytotoxic Activity
Original language description
Lupane compounds occupy an unique position among cytotoxic triterpenoids. In 1976, the cytotoxic effect of the extract of Vauquelinia corymbosa against the lymphocytic leukemia cell line P-388 had already been described. Betulinic acid was subsequently recognized as an active component of this extract. A few years later, its cytotoxic activity (IC50 value of approximately 0.5-1.5 g/mL) on the human melanoma cell line MEL-1 was reported. Since then, interest in this acid and its derivatives has been growing, especially within the pharmaceutical industry. Several years after the publication of the article by Pisha, a new work was published on a group of semisynthetic derivatives of betulin and betulinic acid called betulinines, with significant anticancer effects against a range of tumor cell lines of different histogenetic origin, including multidrug resistant cell types
Czech name
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Czech description
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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