The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33118107" target="_blank" >RIV/61989592:15310/11:33118107 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib
Original language description
Proteasome inhibition is a modern and surprisingly successful approach how to cancer treatment. Bortezomib(Velcade (R)) is a first-in-class proteasome inhibitor and has been approved for first-line treatment of multiple myeloma and second-line treatmentof mantle cell lymphoma. There have been almost 200 clinical trials with bortezomib, both as a single agent and in combination with other drugs, for various cancers, as listed in the US National Cancer Institute database. However, bortezomib's mechanismof action remains elusive despite enormous progress in our knowledge of the cell biology of the ubiquitin-proteasome system (UPS) and bortezomib-induced signaling events in cancer cells. This review maps a rapidly growing and open body of research in both areas.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Pharmaceutical Design
ISSN
1381-6128
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
15
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
17
Pages from-to
1483-1499
UT code for WoS article
000295455800010
EID of the result in the Scopus database
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