Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33140838" target="_blank" >RIV/61989592:15310/12:33140838 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/12:43871074
Result on the web
<a href="http://pubs.acs.org/doi/pdfplus/10.1021/jm201416p" target="_blank" >http://pubs.acs.org/doi/pdfplus/10.1021/jm201416p</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jm201416p" target="_blank" >10.1021/jm201416p</a>

Result language
angličtina
Original language name
Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives
Original language description
The gold(I) complexes of the general formula [Au(L-n)(PPh3)].xH2O (1-8; n = 1-8 and x = 0-1.5), where L-n stands for a deprotonated form of the benzyl-substituted derivatives of 6-benzylaminopurine, were prepared, thoroughly characterized (elemental analyses, FT-IR Raman and multinuclear NMR spectroscopy, ESI+ mass spectrometry, conductivity, DFT calculations), and studied for their in vitro cytotoxicity and in vitro and in vivo anti-inflammatory effects on LPS-activated macrophages (derived from THP-1cell line) and using the carrageenan-induced hind paw edema model on rats. The obtained results indicate that the representative complexes (1, 3, 6) exhibit a strong ability to reduce the production of pro-inflammatory cytoldnes TNF-alpha, IL-1 beta andHMGB1 without influence on the secretion of anti-inflammatory cytokine IL-1RA in the LPS-activated macrophages. The complexes also significantly influence the formation of edema, caused by the intraplantar application of polysaccharide la
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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