Mechanistic insights into toxic effects of a benzotriazolate-bridged dinuclear platinum(II) compound in tumor cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142320" target="_blank" >RIV/61989592:15310/12:33142320 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00389871
Result on the web
<a href="http://dx.doi.org/10.1016/j.ica.2012.06.002" target="_blank" >http://dx.doi.org/10.1016/j.ica.2012.06.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2012.06.002" target="_blank" >10.1016/j.ica.2012.06.002</a>

Result language
angličtina
Original language name
Mechanistic insights into toxic effects of a benzotriazolate-bridged dinuclear platinum(II) compound in tumor cells
Original language description
Toxicity in tumor cells as well as some early phases of the mechanism underlying biological properties of benzotriazolate (Btaz)-bridged dinuclear PtII complex ([{cis-Pt(NH3)2Cl}2(-Btaz-H)]Cl) has been studied. The results of this work afford further details on the mechanism underlying biological effects of bifunctional polynuclear PtII compounds and should provide a more rational basis for the design of new antitumor metallodrugs and chemotherapeutic strategies.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
<a href="/en/project/GAP301%2F10%2F0598" target="_blank" >GAP301/10/0598: Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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