Synthesis of macrocycles containing 1,2,3-triazole motifs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142827" target="_blank" >RIV/61989592:15310/12:33142827 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/12:50000941
Result on the web
<a href="http://dx.doi.org/10.1055/s-0031-1290760" target="_blank" >http://dx.doi.org/10.1055/s-0031-1290760</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/s-0031-1290760" target="_blank" >10.1055/s-0031-1290760</a>

Result language
angličtina
Original language name
Synthesis of macrocycles containing 1,2,3-triazole motifs
Original language description
A new procedure for the preparation of macrocycles with 1,2,3-triazole motifs was developed. The macrocyclic precursor is constructed by repetition of a set of steps that includes a cycloaddition of an azide with an alkyne, alkylation of a carboxylic acid with propargyl bromide and formation of an azide from an amino group. The order of the steps and the size of the connected fragments are determined by the desired ring size. Chromatographic purification techniques for the poorly soluble final productsare also described.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/ME09057" target="_blank" >ME09057: Research of new organic compounds with anticancer activity with use of combinatorial chemistry</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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