Synthesis and cytotoxicity of some D-mannose click conjugates with aminobenzoic acid derivatives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142874" target="_blank" >RIV/61989592:15310/12:33142874 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/12:33142874

Result on the web

<a href="http://dx.doi.org/10.1016/j.carres.2012.08.001" target="_blank" >http://dx.doi.org/10.1016/j.carres.2012.08.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carres.2012.08.001" target="_blank" >10.1016/j.carres.2012.08.001</a>

Result language

angličtina

Original language name

Synthesis and cytotoxicity of some D-mannose click conjugates with aminobenzoic acid derivatives

Original language description

Two sets of new conjugates obtained from D-mannose derivatives and o-, m-, and p-substituted benzoic acid esters interconnected through a triazole ring were synthesized by Cu(I) catalyzed azide-alkyne cycloaddition. All synthesized compounds were testedfor their in vitro cytotoxic activity against seven cancer cell lines with/without multidrug resistance phenotype as well as non-tumor MRC-5 and BJ fibroblasts. Butyl ester of 4-aminobenzoic acid 6c showed the highest activity among all tested compounds,however, it was active only against K562 myeloid leukemia cells. N-Glycosyltriazole conjugates, both acetylated and nonacetylated at mannose moiety, were almost completely inactive. In contrast, some of the acetylated O-glycosyl conjugates showed cytotoxic activity which was cell line dependent and strongly affected by position of benzoic acid substitution as well as a length of its ester alkyl chain; the most potent compound was acetylated mannoside conjugated with octyl ester of m-sub

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carbohydrate Research

ISSN

0008-6215

e-ISSN

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Volume of the periodical

361

Issue of the periodical within the volume

NOV

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

1-6

UT code for WoS article

000310843700001

EID of the result in the Scopus database

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