Small Molecules Penetration Through Membranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33146896" target="_blank" >RIV/61989592:15310/12:33146896 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Small Molecules Penetration Through Membranes
Original language description
Here we report on development of methodology for the calculation of partition and diffusion coefficients of permeants in lipid bilayers, composed namely ofphosphatidylcholineorceramide. The methodology is based on molecular dynamics simulations and it isintended to represent one part of a larger project targeted at calculating bioavailability of permeants via skin absorption. The developed methodology was tested on a set of molecules provided by Procter and Gamble.
Czech name
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Czech description
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Classification
Type
V<sub>souhrn</sub> - Summary research report
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2012
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.
Data specific for result type
Number of pages
31
Place of publication
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Publisher/client name
Procter and Gamble, USA
Version
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