Separation of ketoprofen enantiomers at nanomolar concentration levels by micellar electrokinetic chromatography with on-line electrokinetic preconcentration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147305" target="_blank" >RIV/61989592:15310/13:33147305 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2478/s11532-012-0177-0" target="_blank" >http://dx.doi.org/10.2478/s11532-012-0177-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11532-012-0177-0" target="_blank" >10.2478/s11532-012-0177-0</a>

Result language

angličtina

Original language name

Separation of ketoprofen enantiomers at nanomolar concentration levels by micellar electrokinetic chromatography with on-line electrokinetic preconcentration

Original language description

Separation of enantiomers represents an extremely important task in the field of analytical chemistry. This paper contributes to the field of the on-line preconcentration of enantiomers by developing a novel setup based on the electrokinetic accumulationof ketoprofen enantiomers on the pH boundary followed by enantioselective mobilization by a mixture of SDS, sulfated-beta-cyclodextrin (S-beta-CD), and trimethyl-beta-cyclodextrin (TM-beta-CD). Under the best conditions, where the injection electrolytewas composed of 50 mmol L-1 borate/NaOH pH 9.5 with 60% (v/v) methanol, the background electrolyte contained 50 mmol L-1 phosphate/NaOH pH 2.5, and the mobilization electrolyte consisted of 50 mmol L-1 phosphate/NaOH pH 2.5 with 4.0% (w/v) S-beta-CD, 0.5% (w/v) TM-beta-CD, and 20 mmol L-1 SDS, the determination of nanomolar concentration levels of ketoprofen enantiomers was successful by using micellar electrokinetic chromatography with a common UV detection. LODs were 2.5 nmol L-1 and 3

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Chemistry

ISSN

1895-1066

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

6

Pages from-to

335-340

UT code for WoS article

000312878400003

EID of the result in the Scopus database

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