Toxicity in tumor cells, DNA binding mode, and resistance to decomposition by sulfur nucleophiles of new dinuclear bifunctional trans-PtII complexes containing long alkane linkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147619" target="_blank" >RIV/61989592:15310/13:33147619 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00392664
Result on the web
<a href="http://dx.doi.org/10.1351/PAC-CON-12-07-08" target="_blank" >http://dx.doi.org/10.1351/PAC-CON-12-07-08</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1351/PAC-CON-12-07-08" target="_blank" >10.1351/PAC-CON-12-07-08</a>
Alternative languages
Result language
angličtina
Original language name
Toxicity in tumor cells, DNA binding mode, and resistance to decomposition by sulfur nucleophiles of new dinuclear bifunctional trans-PtII complexes containing long alkane linkers
Original language description
In an effort to design dinuclear Pt(II) compounds that maintain the target (DNA) binding profile of the trans-oriented dinuclear bifunctional PtII complexes containing aliphatic linker chains but are less susceptible to metabolic decomposition, the new,long-chain dinuclear Pt(II) complexes - [{trans-PtCl(dien)}2-?-(CH2)n]2+ (n = 7,10,12, dien = diethylenetriamine) - were synthesized and their antitumor activity evaluated.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GD301%2F09%2FH004" target="_blank" >GD301/09/H004: Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pure and Applied Chemistry
ISSN
0033-4545
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"343?354"
UT code for WoS article
000314208700004
EID of the result in the Scopus database
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