Fast and effective reduction of nitroarenes by sodium dithionite under PTC conditions: application in solid-phase synthesis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147701" target="_blank" >RIV/61989592:15310/13:33147701 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tetlet.2013.03.010" target="_blank" >http://dx.doi.org/10.1016/j.tetlet.2013.03.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetlet.2013.03.010" target="_blank" >10.1016/j.tetlet.2013.03.010</a>

Result language
angličtina
Original language name
Fast and effective reduction of nitroarenes by sodium dithionite under PTC conditions: application in solid-phase synthesis
Original language description
Herein, conditions for the fast and effective reduction of aromatic nitro groups bound to hydrophobic polystyrene-based Wang and Ring resins utilizing sodium dithionite in dichloromethane-water under PTC conditions are reported. Tetrabutylammonium hydrogen sulfate (TBAHS) was found to be an effective phase-transfer catalyst for this reaction. This method allows for the reduction of nitro groups to amino groups under mild conditions with complete conversion and is tolerant of other functional groups. This method is a superior alternative to tin(II) chloride-based reduction, which is known for its shortcomings.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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