Solid-Phase Synthesis Enabling Chemical Diversity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147704" target="_blank" >RIV/61989592:15310/13:33147704 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Solid-Phase Synthesis Enabling Chemical Diversity
Original language description
This chapter describes numerous approaches to arriving at diverse compounds using polymer-supported solid-phase synthesis, including skeletal-, stereochemical-, and appendage diversity-generating processes. It focuses mainly on skeletal diversity, due toits great potential to create diverse heterocyclic compounds, although a combination of strategies such as those described in the build/couple/pair (B/C/P) method provides the most promising potential for diversity creation. The critical advantage of the use of solid-phase chemistry for diversity-oriented synthesis (DOS) resides in a potential to build (and synthesize) a large number of very diverse compounds in a relatively short period of time together with the operational simplicity of the process.In addition, chemical diversity can also be achieved by a scaffold hopping process.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology
ISBN
978-1-118-14565-4
Number of pages of the result
52
Pages from-to
201-252
Number of pages of the book
629
Publisher name
John Wiley & Sons, Inc.
Place of publication
USA
UT code for WoS chapter
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