Study of direct macrocycle formation via the cyclisation of propargyl 2-azidobenzoate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147718" target="_blank" >RIV/61989592:15310/13:33147718 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tetlet.2012.12.076" target="_blank" >http://dx.doi.org/10.1016/j.tetlet.2012.12.076</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetlet.2012.12.076" target="_blank" >10.1016/j.tetlet.2012.12.076</a>

Result language
angličtina
Original language name
Study of direct macrocycle formation via the cyclisation of propargyl 2-azidobenzoate
Original language description
Macrocycles were synthesised via the cyclisation of propargyl 2-azidobenzoate using 'click' chemistry. An LC/MS-based method for the separation of macrocycles is described. In the present work, the influence of various catalysts and reaction conditions on the course of the reaction is evaluated. The reaction is very sensitive to the conditions, and it is demonstrated that it is possible to modify the ratio of macrocycles by varying the reaction conditions. The cyclisation of propargyl 2-azidobenzoate represents an economical method for the preparation of the studied macrocycles
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/ME09057" target="_blank" >ME09057: Research of new organic compounds with anticancer activity with use of combinatorial chemistry</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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