Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147886" target="_blank" >RIV/61989592:15310/13:33147886 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/13:00423094 RIV/00209805:_____/13:#0000431
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0223523413005102" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0223523413005102</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2013.08.009" target="_blank" >10.1016/j.ejmech.2013.08.009</a>
Alternative languages
Result language
angličtina
Original language name
Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines
Original language description
Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Medicinal Chemistry
ISSN
0223-5234
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
OCT
Country of publishing house
FR - FRANCE
Number of pages
7
Pages from-to
253-259
UT code for WoS article
000326902300027
EID of the result in the Scopus database
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