Identification of Genes Essential for the Biogenesis of Quinohemoprotein Amine Dehydrogenase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151051" target="_blank" >RIV/61989592:15310/14:33151051 - isvavai.cz</a>

Result on the web

<a href="http://pubs.acs.org/doi/ipdf/10.1021/bi401625m" target="_blank" >http://pubs.acs.org/doi/ipdf/10.1021/bi401625m</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/bi401625m" target="_blank" >10.1021/bi401625m</a>

Result language

angličtina

Original language name

Identification of Genes Essential for the Biogenesis of Quinohemoprotein Amine Dehydrogenase

Original language description

The structural genes encoding quinohemoprotein amine dehydrogenase (QHNDH) in Gram-negative bacteria constitute a polycistronic operon together with several nearby genes, which are collectively termed "qhp". We previously showed that the qhpD gene, whichlies between qhpA and qhpC (encoding the alfa and gama subunits of QHNDH, respectively), and the qhpE gene, which follows qhpB (encoding the beta subunit), both encode enzymes specifically involved in the posttranslational modification of the gama subunit and are hence essential for QHNDH biogenesis in Paracoccus denitrificans [Ono, K., et al. (2006) J. Biol. Chem. 281, 13672-13684; Nakai, T., et al. (2012) J. Biol. Chem. 287, 6530-6538]. Here we further demonstrate that the qhpF gene, which follows qhpE, and the qhpG and qhpR genes, peripherally located in the complementary strand, are also indispensable for QHNDH biogenesis. The qhpF gene encodes an efflux ABC transporter, which probably translocates the gama subunit into the peripla

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemistry

ISSN

0006-2960

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

895-907

UT code for WoS article

000331342700010

EID of the result in the Scopus database

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