Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151900" target="_blank" >RIV/61989592:15310/14:33151900 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/14:33151900

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0040403914007588" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0040403914007588</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tetlet.2014.04.121" target="_blank" >10.1016/j.tetlet.2014.04.121</a>

Result language

angličtina

Original language name

Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones

Original language description

The targeted solid-phase synthesis of 3-hydroxyquinolin-4(1H)-one derivatives is described. The primary and secondary amines, 3-amino-4-(methoxycarbonyl)benzoic acid and 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone were used as starting materials. The structures of the final compounds were designed in accordance with previous information obtained from structure-activity relationship studies of similar cytotoxic derivatives. Representative prepared compounds were subjected to in vitro screening of cytotoxic activity against various cancer cell lines; the results obtained are discussed. Fluorescence properties of selected compounds were also studied to compare the data with those obtained in analogous derivatives.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tetrahedron Letters

ISSN

0040-4039

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

26

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

3592-3595

UT code for WoS article

000337868300004

EID of the result in the Scopus database

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