Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151965" target="_blank" >RIV/61989592:15310/14:33151965 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3987/COM-14-13026" target="_blank" >http://dx.doi.org/10.3987/COM-14-13026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3987/COM-14-13026" target="_blank" >10.3987/COM-14-13026</a>

Result language
angličtina
Original language name
Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508
Original language description
A regioselective synthesis of dihydropyrazolopyrimidines is reported. The multicomponent reaction of readily available arylaldehydes, Meldrum's acid, and aminopyrazole CAN508 afforded fused pyrazolopyrimidines in high yields. The reaction proceeded regioselectively via initial Michael addition of the exocyclic amino group to arylidene Meldrum's acid intermediate followed by a ring closure at the endocyclic nitrogen of aminopyrazole. The regioselectivity of the reaction was determined by X-ray crystallography.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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