Mesenchymal stromal cell labeling by new uncoated superparamagnetic maghemite nanoparticles in comparison with commercial Resovist - an initial in vitro study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151966" target="_blank" >RIV/61989592:15310/14:33151966 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/14:00078635 RIV/61989592:15110/14:33151966
Result on the web
<a href="http://www.dovepress.com/mesenchymal-stromal-cell-labeling-by-new-uncoated-superparamagnetic-ma-peer-reviewed-article-IJN" target="_blank" >http://www.dovepress.com/mesenchymal-stromal-cell-labeling-by-new-uncoated-superparamagnetic-ma-peer-reviewed-article-IJN</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/IJN.S66986" target="_blank" >10.2147/IJN.S66986</a>

Result language
angličtina
Original language name
Mesenchymal stromal cell labeling by new uncoated superparamagnetic maghemite nanoparticles in comparison with commercial Resovist - an initial in vitro study
Original language description
Cell therapies have emerged as a promising approach in medicine. The basis of each therapy is the injection of 1-100x106 cells with regenerative potential into some part of the body. Mesenchymal stromal cells (MSCs) are the most used cell type in the cell therapy nowadays, but no gold standard for the labeling of the MSCs for magnetic resonance imaging (MRI) is available yet. This work evaluates our newly synthesized uncoated superparamagnetic maghemite nanoparticles (surface-active maghemite nanoparticles - SAMNs) as an MRI contrast intracellular probe usable in a clinical 1.5 T MRI systém.Detailed in vitro tests and phantom tests on ex vivo tissue show that the new SAMNs are efficient MRI contrast agent probes with exclusive intracellular uptake andhigh biological safety.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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