Synthesis of pyridyl substituted pyrazolo[4,3-c]pyridines as potential inhibitors of protein kinases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33152656" target="_blank" >RIV/61989592:15310/14:33152656 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/14:00436360
Result on the web
<a href="http://quod.lib.umich.edu/cache//5/5/5/5550190.p008.188/5550190.p008.188.pdf#page=1;zoom=75" target="_blank" >http://quod.lib.umich.edu/cache//5/5/5/5550190.p008.188/5550190.p008.188.pdf#page=1;zoom=75</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3998/ark.5550190.p008.188" target="_blank" >10.3998/ark.5550190.p008.188</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of pyridyl substituted pyrazolo[4,3-c]pyridines as potential inhibitors of protein kinases
Original language description
A synthetic route towards 3-(2-pyridyl)-6-(hetero)aryl-1H-pyrazolo[4,3-c]pyridines is described. The key step consists of a microwave-assisted multi-component reaction, including a Sonogashira type cross-coupling of appropriate 5-chloropyrazole-4-carbaldehydes with alkynyl(hetero) arenes followed by pyridine ring formation of the coupling products in the presence of tert-butylamine, directly affording the title compounds. A congener without substituent at N-1 was accessed via cleavage of a tert-butyl protecting group. Detailed NMR spectroscopic studies (H-1, C-13 and N-15) were undertaken with the obtained compounds. Selected representatives were evaluated for their potential as inhibitors of protein kinases.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Arkivoc
ISSN
1551-7004
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
135-149
UT code for WoS article
000343046400011
EID of the result in the Scopus database
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