Biologically Active Triterpenoids Usable As Prodrugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33152706" target="_blank" >RIV/61989592:15310/15:33152706 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/15:00447783 RIV/61989592:15110/15:33152706
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Biologically Active Triterpenoids Usable As Prodrugs
Original language description
Triterpenoids are a large group of natural compounds, many of which have interesting biological activities. Despite this, only a few derivatives are currently used as therapeutics. The main reason is that the active triterpenes usually have unfavorable pharmacological and physicochemical properties such as solubility and bioavailability. Therefore, many compounds with excellent activity in in vitro tests usually fail during clinical trial. Many research groups have tried to synthesize a variety of prodrugs in order to improve pharmacological properties of the active compound while retaining the desired biological activity. The most commonly chosen functional groups in triterpenes to be modified as prodrugs are hydroxyl and carboxyl. In this chapter, weare going to summarize all of the research that has been done in the area of triterpenoid prodrugs with the main focus on the modifications of hydroxyls and carboxyls. Commonly used types of prodrug groups (such as simple alkyl esters, o
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Terpenoids and Squalene: Biosynthesis, Functions and Health Implications
ISBN
978-1-63463-656-8
Number of pages of the result
25
Pages from-to
25-49
Number of pages of the book
90
Publisher name
Nova Science Publisher, Inc.
Place of publication
USA
UT code for WoS chapter
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