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New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33155830" target="_blank" >RIV/61989592:15310/15:33155830 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/15:00446237

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0006295215001963" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0006295215001963</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bcp.2015.04.003" target="_blank" >10.1016/j.bcp.2015.04.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells

  • Original language description

    The mechanism of cytotoxic activity of Pt(IV) derivatives of cisplatin with vaproic acid (VPA) axial ligands was examined. The results indicate that the enhanced cytotoxicity of the Pt(IV)-VPA conjugates is a consequence of several processes involving enhanced cellular accumulation, downregulation of histone deacetylases and yet other biochemical processes which may potentiate antitumor effects

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochemical Pharmacology

  • ISSN

    0006-2952

  • e-ISSN

  • Volume of the periodical

    95

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    133-144

  • UT code for WoS article

    000355070000001

  • EID of the result in the Scopus database