Solid-Phase Synthesis of 2-Aryl-3-alkylamino-1H-indoles from 2-Nitro-N-(2-oxo-2-arylethyl)benzenesulfonamides via Base-Mediated C-Arylation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156121" target="_blank" >RIV/61989592:15310/15:33156121 - isvavai.cz</a>

Result on the web

<a href="http://pubs.acs.org/doi/abs/10.1021/co500167g" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/co500167g</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Solid-Phase Synthesis of 2-Aryl-3-alkylamino-1H-indoles from 2-Nitro-N-(2-oxo-2-arylethyl)benzenesulfonamides via Base-Mediated C-Arylation

Original language description

Polymer-supported 2-nitro-N-(2-oxo-2-arylethyl)benzenesulfonamides, prepared from resin-bound amines by sulfonylation with 2-nitrobenzenesulfonyl chlorides followed by alkylation with ?-bromoacetophenones, represent advanced intermediates for the synthesis of different nitrogenous heterocycles. We report their application for the synthesis of 2-aryl-3-alkylamino-1H-indoles via base-mediated C-arylation reactions followed by the reduction of the C-arylated intermediates. Linear precursors for C-arylationwere prepared on solid-phase support from simple, commercially available building blocks. The effects of different substituents on the amino and aryl groups were addressed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP207%2F12%2F0473" target="_blank" >GAP207/12/0473: Solid-phase synthesis of diversely constrained peptidomimetics.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Combinatorial Science

ISSN

2156-8952

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

137-146

UT code for WoS article

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EID of the result in the Scopus database

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