Solid-phase synthesis of fused 1,4-diazepanone peptidomimetics via tandem N-iminium ion cyclization-nucleophilic addition.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156164" target="_blank" >RIV/61989592:15310/15:33156164 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0040403915012964" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0040403915012964</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetlet.2015.08.015" target="_blank" >10.1016/j.tetlet.2015.08.015</a>

Result language
angličtina
Original language name
Solid-phase synthesis of fused 1,4-diazepanone peptidomimetics via tandem N-iminium ion cyclization-nucleophilic addition.
Original language description
We herein describe the solid-phase synthesis of protected N-oxoalkyl-derivatized peptides designed for subsequent acid-mediated, tandem N-acyliminium ion cyclization-nucleophilic addition reaction. The target compounds contained fused 1,4-diazepanones incorporated into a peptide backbone and served as conformational constraints. The scope and limitation of the ring formation were studied, and the structural requirements and reaction conditions for cyclization are outlined.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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