Synthesis, characterization and in vitro cytotoxicity of gold(III) dialkyl/diaryldithiocarbamato complexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156318" target="_blank" >RIV/61989592:15310/15:33156318 - isvavai.cz</a>
Result on the web
<a href="http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra15123f" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra15123f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c5ra15123f" target="_blank" >10.1039/c5ra15123f</a>

Result language
angličtina
Original language name
Synthesis, characterization and in vitro cytotoxicity of gold(III) dialkyl/diaryldithiocarbamato complexes
Original language description
A series of six dialkyl/diaryldithiocarbamato (dtc) gold(III) complexes 1- 6 of the composition [Au(Me(2)dtc)(2)]Cl (1), [Au(Me(2)dtc)Cl-2] (2), [Au(Et(2)dtc)(2)]Cl (3), [Au(Et(2)dtc)Cl-2] (4), [Au(Bn(2)dtc)(2)]Cl (5), [Au(Bn(2)dtc)Cl-2] (6) (dtc = Dithiocarbamate, Me = Methyl, Et = Ethyl and Bn = Benzyl) was synthesised and characterized by elemental analysis, infrared and NMR spectroscopy, and single crystal X-ray analysis in the case of complexes 4 and 5. The anticancer potential of the complexes wasevaluated against MCF7, A2780 and A2780R human cancer cell lines as well as against a healthy MRC5 cell line. The most promising data were obtained for complex 4. It showed similar cytotoxicity as cisplatin against A2780 cells (EC50 approximate to 9.5 mu M vs. EC50 approximate to 10 mu M), and significantly higher cytotoxicity as compared to cisplatin on A2780R and MCF7 cell lines, with EC50 approximate to 2.8 mu M vs. EC50 approximate to 21 mu M, and EC50 approximate to 2.2 mu M vs. EC
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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