Arrival time distributions of product ions reveal isomeric ratio of deprotonated molecules in ion mobility-mass spectrometry of hyaluronan-derived oligosaccharides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156407" target="_blank" >RIV/61989592:15310/15:33156407 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/15:00444977

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/jms.3596/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jms.3596/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jms.3596" target="_blank" >10.1002/jms.3596</a>

Result language

angličtina

Original language name

Arrival time distributions of product ions reveal isomeric ratio of deprotonated molecules in ion mobility-mass spectrometry of hyaluronan-derived oligosaccharides

Original language description

Hyaluronic acid is a naturally occurring linear polysaccharide with substantial medical potential. In this work, discrimination of tyramine-based hyaluronan derivatives was accessed by ion mobility-mass spectrometry of deprotonated molecules and nuclearmagnetic resonance spectroscopy. As the product ion mass spectra did not allow for direct isomer discrimination in mixture, the reductive labeling of oligosaccharides as well as stable isotope labeling was performed. The ion mobility separation of parentions together with the characteristic fragmentation for reduced isomers providing unique product ions allowed us to identify isomers present in a mixture and determine their mutual isomeric ratio. The determination used simple recalculation of arrival time distribution areas of unique ions to areas of deprotonated molecules. Mass spectrometry data were confirmed by nuclear magnetic resonance spectroscopy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Mass Spectrometry

ISSN

1076-5174

e-ISSN

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Volume of the periodical

50

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

854-863

UT code for WoS article

000355618600009

EID of the result in the Scopus database

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