Synthesis and biological activity evaluation of Schiff bases of 5-acyl-1,2,4-triazine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156948" target="_blank" >RIV/61989592:15310/15:33156948 - isvavai.cz</a>
Result on the web
<a href="http://jcsp.org.pk/PublishedVersion/4163c0ab-d5d9-4503-bf16-9fd496a6271dManuscript%20no%2014,%20Final%20Gally%20Proof%20of%2010139%20(Mariusz%20Mojzych).pdf" target="_blank" >http://jcsp.org.pk/PublishedVersion/4163c0ab-d5d9-4503-bf16-9fd496a6271dManuscript%20no%2014,%20Final%20Gally%20Proof%20of%2010139%20(Mariusz%20Mojzych).pdf</a>
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Synthesis and biological activity evaluation of Schiff bases of 5-acyl-1,2,4-triazine
Original language description
A simple and general method has been developed for the synthesis of various Schiff bases (oximes, hydrazones, semicarbazones and thiosemicarbazones) derived from 5-acyl-1,2,4-triazines. Some of the new synthesized Schiff bases were tested for biologicalactivity but only oximes 2a-c shown poor antiviral activity. The oxime derivatives of 5-acyl-3-methylsulfanyl-1,2,4-triazine were tested with pea-seedling diamine oxidase as the enzyme is known to be inhibited by oxime compounds. However, only weak non-competitive inhibitory effects were observed (Ki of 10-2 M).
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA522%2F08%2F0555" target="_blank" >GA522/08/0555: Structure-functional characterization of oxidoreductases acting on nitrogenous regulatory compounds in plants</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)