The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33157029" target="_blank" >RIV/61989592:15310/15:33157029 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/15:00446643
Result on the web
<a href="http://pubs.acs.org/doi/pdf/10.1021/acschembio.5b00151" target="_blank" >http://pubs.acs.org/doi/pdf/10.1021/acschembio.5b00151</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acschembio.5b00151" target="_blank" >10.1021/acschembio.5b00151</a>

Result language
angličtina
Original language name
The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition
Original language description
The effect of halogen-to-hydrogen bond substitution on the binding energetics and biological activity of a human aldose reductase inhibitor has been studied using X-ray crystallography, IC50 measurements, advanced binding free energy calculations, and simulations. The replacement of Br or I atoms by an amine (NH2) group has not induced changes in the original geometry of the complex, which made it possible to study the isolated features of selected noncovalent interactions in a biomolecular complex.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)