Synthesis, characterization, DNA binding studies and in vitro cytotoxicity of platinum(II)-dihalogenido complexes containing bidentate chelating N-donor ligands

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161127" target="_blank" >RIV/61989592:15310/16:33161127 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/00958972.2016.1199862" target="_blank" >http://dx.doi.org/10.1080/00958972.2016.1199862</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/00958972.2016.1199862" target="_blank" >10.1080/00958972.2016.1199862</a>

Result language
angličtina
Original language name
Synthesis, characterization, DNA binding studies and in vitro cytotoxicity of platinum(II)-dihalogenido complexes containing bidentate chelating N-donor ligands
Original language description
Platinum(II) complexes, [Pt(L-x)X-2] (1-6), where X=Br or I and L-x=2,2-bipyridine or 1,10-phenanthroline derivatives (5,5-dimethyl-2,2-bipyridine (5-Mebpy), 4,4-dimethyl-2,2-bipyridine (4-Mebpy), and 5-amino-1,10-phenanthroline (5-NH(2)phen)) were prepared. The complexes were characterized by the elemental analysis, mass spectrometry, infrared, and multinuclear (H-1, C-13 and Pt-195) 1-D and 2-D NMR spectroscopies, and by single-crystal X-ray analysis of [Pt(4-Mebpy)I-2] (4). All the platinum(II) complexes (1-6) were evaluated for in vitro cytotoxicity against human cancer cell lines A2780 and A2780R, and against non-malignant MRC5 cell line. All the complexes were nontoxic up to the 50M concentration, although they were found to readily bind to calf-thymus DNA (CT-DNA), as determined by spectrophotometric titration (K-b approximate to 10(7)M(-1)) and ethidium bromide displacement assay.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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