The use of PAMAM dendrimers as a dynamic coating for cyclodextrin mediated enantioseparation of selected basic drugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161320" target="_blank" >RIV/61989592:15310/16:33161320 - isvavai.cz</a>
Result on the web
<a href="http://pubs.rsc.org/en/content/articlepdf/2016/ay/c5ay03070f" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2016/ay/c5ay03070f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c5ay03070f" target="_blank" >10.1039/c5ay03070f</a>

Result language
angličtina
Original language name
The use of PAMAM dendrimers as a dynamic coating for cyclodextrin mediated enantioseparation of selected basic drugs
Original language description
A dynamic coating using polyamidoamine (PAMAM) dendrimers was used to change the direction and magnitude of electroosmotic flow. The influence of PAMAM on electroosmotic mobility was studied in the concentration range from 0.005 to 0.100% (w/v) and at different electrolyte pH values from 2.5 to 8.5. PAMAM dendrimers, as an additive to the background electrolyte, were able to reverse the electroosmotic flow at a low concentration level (0.01% w/v). The presented dynamic coating was then applied to the enantioseparation of selected amines such as R,S- and S,R-tapentadol, R- and S-isoproterenol and R,S- and S,R-ephedrine with the use of 2-hydroxypropyl-beta-cyclodextrin as the chiral selector.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/GP13-10878P" target="_blank" >GP13-10878P: Study and characterization of novel chemical capillary wall modifications for capillary electrophoresis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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