Oxytetracycline Delivery in Adult Female Zebrafish by Iron Oxide Nanoparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33162072" target="_blank" >RIV/61989592:15310/16:33162072 - isvavai.cz</a>

Result on the web

<a href="http://online.liebertpub.com/doi/pdf/10.1089/zeb.2016.1302" target="_blank" >http://online.liebertpub.com/doi/pdf/10.1089/zeb.2016.1302</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/zeb.2016.1302" target="_blank" >10.1089/zeb.2016.1302</a>

Result language

angličtina

Original language name

Oxytetracycline Delivery in Adult Female Zebrafish by Iron Oxide Nanoparticles

Original language description

Recently, the indiscriminate use of antibiotics in the aquaculture sector has raised public concern because of possible toxic effects, development of bacterial resistance, and accumulation of residues in individual tissues. Even if several countries have developed regulations about their use, it is clear that long-term growth of the aquaculture industry requires both ecologically sound practices and sustainable resource management. Alternative strategies for better management of antibiotic administration are of primary interest to improve absorption rates and, as a consequence, to reduce their release into the aquatic environment. The present study investigates, for the first time to our knowledge, a new methodology for oxytetracycline (OTC) administration through the use of iron oxide nanoparticles (NPs) (made of maghemite -Fe2O3) in zebrafish (Danio rerio). Fish were divided into 4 experimental groups: control; group A exposed to 4mg/L OTC (through water); group B exposed to the 100mg/L SAMNs@OTC complex (equivalent to 4mg/L OTC), and group C exposed to bare NPs. No detoxification processes or anatomical alterations were observed in fish exposed to bare NPs. Exposure of fish to the SAMNs@OTC complex resulted in a 10 times higher OTC accumulation with respect to using water exposure. This new OTC administration method seems much more efficient with respect to the traditional way of exposure and has the potentiality to reduce antibiotic utilization and possible environmental impacts. However, the dynamics related to OTC release from the SAMNs@OTC complex are still not clear and need further investigations.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

—

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Zebrafish

ISSN

1545-8547

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

495-503

UT code for WoS article

000389418100005

EID of the result in the Scopus database

—