Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73580954" target="_blank" >RIV/61989592:15310/17:73580954 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pubmed/28676325" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/28676325</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fct.2017.07.001" target="_blank" >10.1016/j.fct.2017.07.001</a>
Alternative languages
Result language
angličtina
Original language name
Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation
Original language description
Recently, Omidian et al. reported the beneficial effects of divers polyphenols on cellular damage caused by benzo(a)pyrene (BaP) (Omidian et al., 2017). Test polyphenols comprised resveratrol, quercetin, catechin, cyanidin, kuromanin and berberine. In particular, the protective and anti-carcinogenic effects of polyphenols involved: (i) prevention of BaP-induced generation of reactive oxygen species (ROS); (ii) inhibition of BaP-mediated production of mitochondrial superoxide; (iii) inhibition (down-regulation) of BaP-dependent induction of genes related to oxidative stress and inflammation, including UCP2 and TNFa; (iv) inhibition of BaPinduced cell transformation to neoplastic colonies; (v) inhibition of cell proliferation increased by BaP.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA17-02718S" target="_blank" >GA17-02718S: INTERACTIONS OF ESSENTIAL OILS FROM CULINARY SPICES AND HERBS WITH ENDOCRINE AND DETOXICATION SIGNALLING PATHWAYS</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Food and Chemical Toxicology
ISSN
0278-6915
e-ISSN
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Volume of the periodical
107
Issue of the periodical within the volume
SEP
Country of publishing house
GB - UNITED KINGDOM
Number of pages
3
Pages from-to
523-525
UT code for WoS article
000407982900048
EID of the result in the Scopus database
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