Kinase Inhibitor Indole Derivatives as Anticancer Agents: A Patent Review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73584882" target="_blank" >RIV/61989592:15310/17:73584882 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2174/1574892811666161003112119" target="_blank" >http://dx.doi.org/10.2174/1574892811666161003112119</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1574892811666161003112119" target="_blank" >10.2174/1574892811666161003112119</a>

Result language

angličtina

Original language name

Kinase Inhibitor Indole Derivatives as Anticancer Agents: A Patent Review

Original language description

Cancer accounts for a number of deaths each year. Consequently, prevention of this deadly disease is more challenging and hence the invention of new anticancer agents is of utmost importance. The current review elaborates the importance of indole designs as patented in the form of anticancer drug-like molecules targeting different cites of biological arena. Specific attention was given to kinases such as platelet-derived growth factor receptor, vascular endothelial growth factor receptor and fibroblast growth factor receptor, Bruton&apos;s tyrosine kinase, anaplastic lymphoma kinase, Janus kinase, cyclin-dependent kinase aurora kinases A, B and C, checkpoint kinases, protein kinase R, Pim kinases, phosphoinositide 3kinase, altered proteins kinases, polo-like kinase and many more. Moreover, the article summarizes the mode of action through the particular functions of kinases and the inhibitory potential of indole derivatives toward specific kinase. Certain patents gathered in the existing review article suggest that indole core can be a versatile foundation to discover drug-like kinase inhibitor molecules and modification of substituents existing on the indole moiety may have important impact on the pharmacokinetic and pharmacodynamics aspects of the resultant scaffolds. The information presented here would gather a great deal of interest to identify the new molecular designs bearing indole nucleus presenting novel anticancer drugs with a wide variety of biological targets involved in cancer pathology focusing on the inhibition of tyrosine kinases, serine/ threonine-specific protein kinases, cyclin-dependent kinases, lipid kinases and altered protein kinases.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/LM2015073" target="_blank" >LM2015073: Nanomaterials and Nanotechnologies for Environment Protection and Sustainable Future</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Recent Patents on Anti-Cancer Drug Discovery

ISSN

1574-8928

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

1

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

18

Pages from-to

55-72

UT code for WoS article

000397249100006

EID of the result in the Scopus database

2-s2.0-85011015033