Amphiphilic derivatives of (3 beta,17 beta)-3-hydroxyandrost-5-ene-17-carboxylic acid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73585166" target="_blank" >RIV/61989592:15310/17:73585166 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0039128X17301915" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0039128X17301915</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2017.10.011" target="_blank" >10.1016/j.steroids.2017.10.011</a>
Alternative languages
Result language
angličtina
Original language name
Amphiphilic derivatives of (3 beta,17 beta)-3-hydroxyandrost-5-ene-17-carboxylic acid
Original language description
A series of amphiphilic derivatives of (3 beta,17 beta)-3-hydroxyandrost-5-ene-17-carboxylic acid (1) with the poly amine spermine and three other diamines, 1,2-diaminoethane, piperazine and cadaverine, were synthesized and their antimicrobial activity and cytotoxicity were investigated. Among the target compounds, several ones showed antimicrobial activity on Gram positive and Gram negative microorganisms. The most active compounds were 20 (Streptococcus mutans CCM 7409, 3.125 mu M), 16 (Streptococcus mutans CCM 7409, 12.5 mu M) and 10d (Escherichia colt CCM 3954, 12.5 mu M). In addition, compounds 5d, 10d, 13 and 20 displayed cytotoxicity on CEM (12.1 +/- 2.1 mu M, 7.6 +/- 1.0 mu M, 19.0 +/- 0.4 mu M and 5.9 +/- 0.7 mu M, respectively). Two additional compounds displayed medium cytotoxicity on CEM, 5a (34.6 +/- 5.2 mu M) and 5c (37.7 +/- 5.9 mu M). The compound 13 and 20 displayed high toxicity also on normal fibroblasts.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GP14-27669P" target="_blank" >GP14-27669P: The study of molecular mechanisms of anticancer and antiangiogenic activities of brassinosteroids</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
—
Volume of the periodical
128
Issue of the periodical within the volume
DEC
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"58 "- 67
UT code for WoS article
000418216100009
EID of the result in the Scopus database
2-s2.0-85032957676