An alkyne rod to constrain a peptide backbone in an extended conformation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73591227" target="_blank" >RIV/61989592:15310/18:73591227 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201800979" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201800979</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201800979" target="_blank" >10.1002/ejoc.201800979</a>

Result language
angličtina
Original language name
An alkyne rod to constrain a peptide backbone in an extended conformation
Original language description
An N,N′-bound rod-shaped diyne bridge was introduced into a peptide to constrain the peptide backbone in an extended conformation. Linear precursors were achieved via solid-phase synthesis using simple commercially available building blocks. Subsequently, 13- to 15-membered peptide macrocycles were obtained in excellent crude purity via in solution copper-catalyzed cyclization. Density functional theory calculations of the lowest energy conformers suggested that the strain inside the macrocycle caused only slight deformation of the binding angles of the butadiyne moiety.
Czech name
—
Czech description
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Project
<a href="/en/project/GA16-06446S" target="_blank" >GA16-06446S: From Amino Acids to Nature-Inspired Molecular Scaffolds</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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