Intrinsic photoluminescence of amine-functionalized graphene derivatives for bioimaging applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73597856" target="_blank" >RIV/61989592:15310/19:73597856 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2352940719305633" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352940719305633</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apmt.2019.08.002" target="_blank" >10.1016/j.apmt.2019.08.002</a>
Alternative languages
Result language
angličtina
Original language name
Intrinsic photoluminescence of amine-functionalized graphene derivatives for bioimaging applications
Original language description
Photoluminescent graphene-based materials have enormous application potential in cell imaging, display technologies, biomedicine and biosensing. Therefore, their development represents a principal yet highly challenging task for graphene chemistry. Up to now, strategies based on the size confinement in graphene/graphene oxide (GO) quantum dots, non-covalent chemistry combining GO with photoluminescence species, and GO chemistry enabling band gap tuning have been reported. Here, we introduce a simple approach to intrinsically photoluminescent graphene derivatives via one-step fluorographene chemistry enabling controlled surface engineering/chemical reduction by amines. Specifically, the reaction of fluorographene with dodecylamine and hexamethylenediamine results in organophilic and hydrophilic graphene derivatives, respectively, exhibiting intrinsic fluorescence. Both density functional theory calculations and experimental data show that the emission properties occur because of the energy gaps engineered by the choice of amine. Cytotoxicity measurements on NIH/3T3 and HeLa cells demonstrated high biocompatibility for the hydrophilic amine-functionalized derivative. Due to the intrinsic fluorescence, quantification of the uptake by cells and localization of graphene-based sheets in cells can be performed directly using a flow cytometry technique and fluorescence microscopy imaging. These findings pave the way for a new class of functional photoluminescent graphene derivatives with high application potential in fields like biosensing, biomedicine and bioimaging.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Materials Today
ISSN
2352-9407
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
DEC
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
112-122
UT code for WoS article
000502851600007
EID of the result in the Scopus database
2-s2.0-85070708988