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Intrinsic photoluminescence of amine-functionalized graphene derivatives for bioimaging applications

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73597856" target="_blank" >RIV/61989592:15310/19:73597856 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S2352940719305633" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352940719305633</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.apmt.2019.08.002" target="_blank" >10.1016/j.apmt.2019.08.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Intrinsic photoluminescence of amine-functionalized graphene derivatives for bioimaging applications

  • Original language description

    Photoluminescent graphene-based materials have enormous application potential in cell imaging, display technologies, biomedicine and biosensing. Therefore, their development represents a principal yet highly challenging task for graphene chemistry. Up to now, strategies based on the size confinement in graphene/graphene oxide (GO) quantum dots, non-covalent chemistry combining GO with photoluminescence species, and GO chemistry enabling band gap tuning have been reported. Here, we introduce a simple approach to intrinsically photoluminescent graphene derivatives via one-step fluorographene chemistry enabling controlled surface engineering/chemical reduction by amines. Specifically, the reaction of fluorographene with dodecylamine and hexamethylenediamine results in organophilic and hydrophilic graphene derivatives, respectively, exhibiting intrinsic fluorescence. Both density functional theory calculations and experimental data show that the emission properties occur because of the energy gaps engineered by the choice of amine. Cytotoxicity measurements on NIH/3T3 and HeLa cells demonstrated high biocompatibility for the hydrophilic amine-functionalized derivative. Due to the intrinsic fluorescence, quantification of the uptake by cells and localization of graphene-based sheets in cells can be performed directly using a flow cytometry technique and fluorescence microscopy imaging. These findings pave the way for a new class of functional photoluminescent graphene derivatives with high application potential in fields like biosensing, biomedicine and bioimaging.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Applied Materials Today

  • ISSN

    2352-9407

  • e-ISSN

  • Volume of the periodical

    17

  • Issue of the periodical within the volume

    DEC

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    11

  • Pages from-to

    112-122

  • UT code for WoS article

    000502851600007

  • EID of the result in the Scopus database

    2-s2.0-85070708988