A New Hyaluronan Modified with beta-Cyclodextrin on Hydroxymethyl Groups Forms a Dynamic Supramolecular Network
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73598520" target="_blank" >RIV/61989592:15310/19:73598520 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1420-3049/24/21/3849/htm" target="_blank" >https://www.mdpi.com/1420-3049/24/21/3849/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules24213849" target="_blank" >10.3390/molecules24213849</a>
Alternative languages
Result language
angličtina
Original language name
A New Hyaluronan Modified with beta-Cyclodextrin on Hydroxymethyl Groups Forms a Dynamic Supramolecular Network
Original language description
A new hyaluronan derivative modified with beta-cyclodextrin units (CD-HA) was prepared via the click reaction between propargylated hyaluronan and monoazido-cyclodextrin (CD) to achieve a degree of substitution of 4%. The modified hyaluronan was characterized by H-1-nuclear magnetic resonance spectroscopy (NMR) and size exclusion chromatography. Subsequent H-1-NMR and isothermal calorimetric titration experiments revealed that the CD units on CD-HA can form virtual 1:1, 1:2, and 1:3 complexes with one-, two-, and three-site adamantane-based guests, respectively. These results imply that the CD-HA chains used the multitopic guests to form a supramolecular cross-linked network. The free CD-HA polymer was readily restored by the addition of a competing macrocycle, which entrapped the cross-linking guests. Thus, we demonstrated that the new CD-HA polymer is a promising component for the construction of chemical stimuli-responsive supramolecular architectures.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOLECULES
ISSN
1420-3049
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
21
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
"3849-1"-"3849-11"
UT code for WoS article
000498055500038
EID of the result in the Scopus database
2-s2.0-85074204201