Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73603800" target="_blank" >RIV/61989592:15310/20:73603800 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/21/23/9160/htm" target="_blank" >https://www.mdpi.com/1422-0067/21/23/9160/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21239160" target="_blank" >10.3390/ijms21239160</a>
Alternative languages
Result language
angličtina
Original language name
Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application
Original language description
Drug discovery efforts largely depend on access to structural diversity. Multicomponent reactions allow for time-efficient chemical transformations and provide advanced intermediates with three or four points of diversification for further expansion to a structural variety of organic molecules. This review is aimed at solid-phase syntheses of small molecules involving isocyanide-based multicomponent reactions. The majority of all reported syntheses employ the Ugi four-component reaction. The review also covers the Passerini and Groebke-Blackburn-Bienaymé reactions. To date, the main advantages of the solid-phase approach are the ability to prepare chemical libraries intended for biological screening and elimination of the isocyanide odor. However, the potential of multicomponent reactions has not been fully exploited. The unexplored avenues of these reactions, including chiral frameworks, DNA-encoded libraries, eco-friendly synthesis, and chiral auxiliary reactions, are briefly outlined.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
23
Country of publishing house
CH - SWITZERLAND
Number of pages
48
Pages from-to
"9160-1"-"9160-48"
UT code for WoS article
000597528400001
EID of the result in the Scopus database
2-s2.0-85097125292