Dextrans as Permeation Markers and Carriers for Oral Transmucosal Drug Delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604243" target="_blank" >RIV/61989592:15310/20:73604243 - isvavai.cz</a>
Result on the web
<a href="http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3673" target="_blank" >http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3673</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Dextrans as Permeation Markers and Carriers for Oral Transmucosal Drug Delivery
Original language description
Dextrans are studied as markers of oral transmucosal permeability and as possible drug carriers. The therapeutic use of dextrans is primarily limited to the intravenous route of administration. This work focuses on extending the knowledge of dextran permeation by the sublingual route. First, it is documented that non-keratinized sublingual membranes are very sensitive to heat treatment and storage conditions (more than skin membranes). Slow freezing disrupts them seriously, leading to disproportionately high permeability values, even for dextrans with a molecular weight higher than 20 kDa, which, however, may well serve as permeation markers. The dextran gyration radius reflects in vitro oral transmucosal permeability characteristics more appropriately than the pertinent molecular weight values. Macromolecular systems with a gyration radius analogous to 4 kDa dextran, possibly coupled with low molecular weight drugs, have sufficient potential for sublingual systemic drug delivery.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CHEMICKE LISTY
ISSN
0009-2770
e-ISSN
—
Volume of the periodical
114
Issue of the periodical within the volume
8
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
552-558
UT code for WoS article
000558763200007
EID of the result in the Scopus database
2-s2.0-85089475370