Influence of Dextran molecular weight on the physical properties of magnetic nanoparticles for hyperthermia and MRI applications.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73605009" target="_blank" >RIV/61989592:15310/20:73605009 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2079-4991/10/12/2468/htm" target="_blank" >https://www.mdpi.com/2079-4991/10/12/2468/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nano10122468" target="_blank" >10.3390/nano10122468</a>
Alternative languages
Result language
angličtina
Original language name
Influence of Dextran molecular weight on the physical properties of magnetic nanoparticles for hyperthermia and MRI applications.
Original language description
Dextran-coated magnetic nanoparticles are promising biocompatible agents in various biomedical applications, including hyperthermia and magnetic resonance imaging (MRI). However, the influence of dextran molecular weight on the physical properties of dextran-coated magnetic nanoparticles has not been described sufficiently. We synthesise magnetite nanoparticles with a dextran coating using a co-precipitation method and study their physical properties as a function of dextran molecular weight. Several different methods are used to determine the size distribution of the particles, including microscopy, dynamic light scattering, differential centrifugal sedimentation and magnetic measurements. The size of the dextran-coated particles increases with increasing dextran molecular weight. We find that the molecular weight of dextran has a significant effct on the particle size, efficiency, magnetic properties and specific absorption rate. Magnetic hyperthermia measurements show that heating is faster for dextran-coated particles with higher molecular weight. The different molecular weights of the coating also significantly affcted its MRI relaxation properties, especially the transversal relaxivity r2. Linear regression analysis reveals a statistically significant dependence of r2 on the differential centrifugal sedimentation diameter. This allows the targeted preparation of dextran-coated magnetic nanoparticles with the desired MRI properties. These results will aid the development of functionalised magnetic nanoparticles for hyperthermia and MRI applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomaterials
ISSN
2079-4991
e-ISSN
2079-4991
Volume of the periodical
10
Issue of the periodical within the volume
DEC
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
"2468-1"-"2468-18"
UT code for WoS article
000602389400001
EID of the result in the Scopus database
2-s2.0-85103841945