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Synthesis, characterization and cytotoxic evaluation of chalcone derivatives

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73610778" target="_blank" >RIV/61989592:15310/22:73610778 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0022286021021219" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022286021021219</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.molstruc.2021.132001" target="_blank" >10.1016/j.molstruc.2021.132001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis, characterization and cytotoxic evaluation of chalcone derivatives

  • Original language description

    Four chalcones, (E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one (A), (E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one (B), (E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (C) and (E)-3-(4-bromophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (D), were synthesized and characterized by H-1 and C-13 solution-state NMR, C-13 solid-state NMR and single-crystal X-ray diffraction. The different interactions (hydrogen bonding and pi-interactions) observed in the crystal structures of these four molecules were confirmed in the solid-state data as well as in the Hirshfeld surface analysis. The in vitro cytotoxicity of these molecules was also evaluated against human acute lymphoblastic leukemia (CEM), human breast adenocarcinoma (MCF7), human cervical carcinoma (HeLa), human malignant melanoma cell lines (G-361), and normal human skin fibroblasts (BJ). A, B, C and D displayed cytotoxicity in at least two cell lines. A, B, and C were strongly cytotoxic against CEM cells while B and C showed selectivity by not affecting the growth of the normal human skin fibroblasts.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF MOLECULAR STRUCTURE

  • ISSN

    0022-2860

  • e-ISSN

    1872-8014

  • Volume of the periodical

    1251

  • Issue of the periodical within the volume

    MAR

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    9

  • Pages from-to

    "132001-1"-"132001-9"

  • UT code for WoS article

    000744674400010

  • EID of the result in the Scopus database

    2-s2.0-85121125548