Synthesis, characterization and cytotoxic evaluation of chalcone derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73610778" target="_blank" >RIV/61989592:15310/22:73610778 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0022286021021219" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022286021021219</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molstruc.2021.132001" target="_blank" >10.1016/j.molstruc.2021.132001</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, characterization and cytotoxic evaluation of chalcone derivatives
Original language description
Four chalcones, (E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one (A), (E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one (B), (E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (C) and (E)-3-(4-bromophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (D), were synthesized and characterized by H-1 and C-13 solution-state NMR, C-13 solid-state NMR and single-crystal X-ray diffraction. The different interactions (hydrogen bonding and pi-interactions) observed in the crystal structures of these four molecules were confirmed in the solid-state data as well as in the Hirshfeld surface analysis. The in vitro cytotoxicity of these molecules was also evaluated against human acute lymphoblastic leukemia (CEM), human breast adenocarcinoma (MCF7), human cervical carcinoma (HeLa), human malignant melanoma cell lines (G-361), and normal human skin fibroblasts (BJ). A, B, C and D displayed cytotoxicity in at least two cell lines. A, B, and C were strongly cytotoxic against CEM cells while B and C showed selectivity by not affecting the growth of the normal human skin fibroblasts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF MOLECULAR STRUCTURE
ISSN
0022-2860
e-ISSN
1872-8014
Volume of the periodical
1251
Issue of the periodical within the volume
MAR
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
"132001-1"-"132001-9"
UT code for WoS article
000744674400010
EID of the result in the Scopus database
2-s2.0-85121125548