Antibacterial nanomaterials: Upcoming hope to overcome antibiotic resistance crisis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73615759" target="_blank" >RIV/61989592:15310/22:73615759 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/document/doi/10.1515/ntrev-2022-0059/html" target="_blank" >https://www.degruyter.com/document/doi/10.1515/ntrev-2022-0059/html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/ntrev-2022-0059" target="_blank" >10.1515/ntrev-2022-0059</a>
Alternative languages
Result language
angličtina
Original language name
Antibacterial nanomaterials: Upcoming hope to overcome antibiotic resistance crisis
Original language description
When combined with nanomaterials, antibiotics show antibacterial activity against susceptible and resistant bacterial strains at significantly lower concentrations. Unfortunately, to date, no research study has examined the effect of the antibiotic mode of action and mechanism of bacterial resistance on the effectiveness of combined antibacterial treatment with nanomaterials. Therefore, in this review, we performed a thorough analysis and critical evaluation of previously published data related to the combined antibacterial effect of antibiotics with nanostructured materials with a targeted focus on relationships between antibiotic's modes of action and bacterial resistance mechanisms for relevant nanomaterials and their impact on the resulting synergistic effects. Following thorough data analysis and critical discussion, we have discovered and are the first who present that antibiotic's mode of action and bacterial resistance mechanism determine the final effectiveness of combined antibacterial treatment with nanomaterials. We therefore conclude that only certain combinations of nanomaterials with antibiotics can lead to the enhancement and restoration of the antibacterial effectiveness of antibiotics against certain resistant bacteria. Moreover, the recently occurring development of bacterial resistance towards nanomaterials is also discussed together with a possibility of how to prevent it. All discovered findings provide a new view and perspective on this issue helping to navigate further approaches to combat the antibiotic crisis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanotechnology Reviews
ISSN
2191-9089
e-ISSN
2191-9097
Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
28
Pages from-to
1115-1142
UT code for WoS article
000766206000001
EID of the result in the Scopus database
2-s2.0-85126918934