Anticancer Applications of Essential Oils Formulated into Lipid-Based Delivery Nanosystems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73616755" target="_blank" >RIV/61989592:15310/22:73616755 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1999-4923/14/12/2681" target="_blank" >https://www.mdpi.com/1999-4923/14/12/2681</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pharmaceutics14122681" target="_blank" >10.3390/pharmaceutics14122681</a>
Alternative languages
Result language
angličtina
Original language name
Anticancer Applications of Essential Oils Formulated into Lipid-Based Delivery Nanosystems
Original language description
The use of natural compounds is becoming increasingly popular among patients, and there is a renewed interest among scientists in nature-based bioactive agents. Traditionally, herbal drugs can be taken directly in the form of teas/decoctions/infusions or as standardized extracts. However, the disadvantages of natural compounds, especially essential oils, are their instability, limited bioavailability, volatility, and often irritant/allergenic potential. However, these active substances can be stabilized by encapsulation and administered in the form of nanoparticles. This brief overview summarizes the latest results of the application of nanoemulsions, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers used as drug delivery systems of herbal essential oils or used directly for their individual secondary metabolites applicable in cancer therapy. Although the discussed bioactive agents are not typical compounds used as anticancer agents, after inclusion into the aforesaid formulations improving their stability and bioavailability and/or therapeutic profile, they indicated anti-tumor activity and became interesting agents with cancer treatment potential. In addition, co-encapsulation of essential oils with synthetic anticancer drugs into nanoformulations with the aim to achieve synergistic effect in chemotherapy is discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutics
ISSN
1999-4923
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
22
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
"2681-1"-"2681-22"
UT code for WoS article
000904173400001
EID of the result in the Scopus database
2-s2.0-85144891949