Disulfide re-bridging reagents for single-payload antibody-drug conjugates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73620847" target="_blank" >RIV/61989592:15310/23:73620847 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2023/cc/d3cc02980h" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2023/cc/d3cc02980h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D3CC02980H" target="_blank" >10.1039/D3CC02980H</a>

Result language
angličtina
Original language name
Disulfide re-bridging reagents for single-payload antibody-drug conjugates
Original language description
Numerous antibody-drug conjugate (ADC) linker technologies exist for the synthesis of ADCs with drug-to-antibody ratios (DARs) being an even integer (typically 2, 4 or 8). However, ADCs with odd-integer DARs are significantly harder to synthesise. Here, we report the synthesis of ADCs loaded with a single warhead, using TetraDVP linkers which simultaneously re-bridge all four interchain disulfides of an IgG1 antibody
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GN22-07138O" target="_blank" >GN22-07138O: Conformationally-constrained peptide-drug conjugates as a platform for targeted therapeutics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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