Site-Selective Peptide Functionalisation Mediated via Vinyl-Triazine Linchpins

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F24%3A73626664" target="_blank" >RIV/61989592:15310/24:73626664 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2024/cc/d3cc05213c" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2024/cc/d3cc05213c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D3CC05213C" target="_blank" >10.1039/D3CC05213C</a>

Result language
angličtina
Original language name
Site-Selective Peptide Functionalisation Mediated via Vinyl-Triazine Linchpins
Original language description
Herein we introduce 3-vinyl-1,2,4-triazines derivatives as dual-reactive linkers that exhibit selectivity towards cysteine and specific strained alkynes, enabling conjugate addition and inverse electron-demand Diels-Alder (IEDDA) reactions. This approach facilitates site-selective bioconjugation of biologically relevant peptides, followed by rapid and highly selective reactions with bicyclononyne (BCN) reagents.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GN22-07138O" target="_blank" >GN22-07138O: Conformationally-constrained peptide-drug conjugates as a platform for targeted therapeutics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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