Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F24%3A73628425" target="_blank" >RIV/61989592:15310/24:73628425 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2075-4450/15/10/797" target="_blank" >https://www.mdpi.com/2075-4450/15/10/797</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/insects15100797" target="_blank" >10.3390/insects15100797</a>

Result language

angličtina

Original language name

Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences

Original language description

Increased levels of reactive oxygen species (ROS) produced during aerobic metabolism in animals can negatively affect the intracellular redox status, cause oxidative stress and interfere with physiological processes in the cells. The antioxidant defence regulates ROS levels by interplaying diverse enzymes and non-enzymatic metabolites. The thioredoxin system, consisting of the enzyme thioredoxin reductase (TrxR), the redox-active protein thioredoxin (Trx) and NADPH, represent a crucial component of antioxidant defence. It is involved in the signalling and regulation of multiple developmental processes, such as cell proliferation or apoptotic death. Insects have evolved unique variations of TrxR, which resemble mammalian enzymes in overall structure and catalytic mechanisms, but the selenocysteine-cysteine pair in the active site is replaced by a cysteine-cysteine pair typical of bacteria. Moreover, the role of the thioredoxin system in insects is indispensable due to the absence of glutathione reductase, an essential enzyme of the glutathione system. However, the functions of the Trx system in insects are still poorly characterised. In the present review, we provide a critical overview of the current knowledge on the insect Trx system, focusing mainly on TrxR&apos;s role in the antioxidant and immune system of model insect species.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/LUAUS24085" target="_blank" >LUAUS24085: BeeBrilliant: Exploring the keys of honey bee resilience through a combination of genomic, biochemical and geoinformatics approaches</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Insects

ISSN

2075-4450

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

30

Pages from-to

"797-1"-"797-30"

UT code for WoS article

001341915300001

EID of the result in the Scopus database

2-s2.0-85207639513